Job Description

NGS Lab Associate Scientist

Breakthrough Genomics, Inc.

Location: Irvine, California

Employment Type: Per diem

Department: Clinical Laboratory / Genomics Operations

About Breakthrough Genomics

Breakthrough Genomics, Inc. is a CAP-accredited and CLIA-certified clinical genomics laboratory focused on advancing next-generation sequencing, genomic medicine, and AI-powered variant interpretation. Our mission is to accelerate rare disease and common disease diagnosis by combining high-quality laboratory testing with advanced bioinformatics and our Virtual Geneticist interpretation platform.

We are seeking a motivated and detail-oriented NGS Lab Associate Scientist to join our growing clinical genomics laboratory team.

Position Summary

The NGS Lab Associate Scientist will support daily next-generation sequencing laboratory operations, including DNA/RNA sample processing, library preparation, sequencing workflow execution, quality control, documentation, and compliance with CLIA/CAP laboratory standards.

This role is ideal for someone with hands-on molecular biology experience, strong attention to detail, and an interest in clinical genomics, rare disease diagnostics, and precision medicine.

Key Responsibilities

• Perform NGS laboratory workflows, including DNA/RNA extraction, quantification, quality assessment, library preparation, target enrichment, and sequencing.
• Operate and maintain laboratory instruments used in molecular genetics and NGS workflows.
• Perform quality control checks and accurately document experimental results, reagent usage, sample tracking, and deviations.
• Assist with clinical sample accessioning, processing, and workflow coordination.
• Support validation studies, assay optimization, troubleshooting, and process improvement projects.
• Follow established SOPs, safety procedures, and quality management system requirements.
• Maintain accurate records in compliance with CLIA, CAP, and internal laboratory policies.
• Collaborate with laboratory directors, scientists, bioinformatics teams, and operations staff to ensure timely and accurate testing.
• Participate in inventory management, reagent preparation, equipment maintenance, and general laboratory organization.
• Support continuous improvement of laboratory efficiency, quality, and scalability.

QualificationsRequired

• Bachelor’s degree in Molecular Biology, Genetics, Biochemistry, Biotechnology, Biology, or a related life science field.
• Hands-on laboratory experience in molecular biology techniques such as DNA/RNA extraction, PCR, qPCR, gel electrophoresis, or NGS library preparation.
• Strong attention to detail and ability to follow SOPs precisely.
• Excellent organizational, documentation, and communication skills.
• Ability to work independently and collaboratively in a fast-paced laboratory environment.
• Commitment to quality, accuracy, and patient-centered clinical testing.

Preferred

• Experience with next-generation sequencing workflows, including WES, WGS, RNA-seq, panel sequencing, or methylation sequencing.
• Familiarity with laboratory information management systems, sample tracking, and quality control documentation.
• Experience with Illumina, MGI, or other sequencing platforms.
• Knowledge of clinical genetics, rare disease testing, oncology genomics, or molecular diagnostics.
• Experience with assay validation, troubleshooting, and process development.

Desired Skills

• Strong pipetting and sample handling skills.
• Ability to manage multiple samples and workflows with accuracy.
• Understanding of contamination control and molecular laboratory best practices.
• Comfortable working with deadlines and clinical turnaround time expectations.
• Interest in applying genomics and AI to improve patient diagnosis.

Why Join Breakthrough Genomics?

At Breakthrough Genomics, you will have the opportunity to work at the intersection of clinical genomics, advanced sequencing technology, and AI-driven interpretation. You will contribute directly to diagnostic testing that can help patients and families find answers.

We offer a collaborative, innovative, and mission-driven environment where your laboratory work has real clinical impact.

How to Apply

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Please include “NGS Lab Associate Scientist Application” in the subject line.

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